In boxbehnken design, cellulose acetate, polyethylene glycol, and sorbitol were used as variables and %captopril release as a response. Optimization and development of swellable controlled porosity. Already optimized core tablets of captopril were used for the application of cpop. The aim of the present study was to develop pegylated cellulose acetate coating layer having leachable membrane created by controlled porosity osmotic pump cpop technique.
A at least one active agent surrounded by b a rate controlling water insoluble wall, having a fluid permeability of 6. Abstractbackground the osmotic drug delivery systems suitable for oral administration. Unlike the elementary osmotic pump eop which consists of an osmotic core with the drug surrounded by a semipermeable membrane drilled with a delivery orifice, controlled porosity of the membrane is accomplished by the use of different channeling. L oros hard cap, l oros soft cap and delayed liquid bolus delivery system, telescopic capsule, 23 oros ct, 24 sandwiched osmotic. Effervescent elementary osmotic pump modified osmotic pump 1. The aim of this study was to formulate controlled porosity osmotic pump cpop tablets containing venlafaxine hydrochloride to be taken once daily. When the controlled porosity osmotic pump tablets are in aqueous environment the water soluble additives get dissolved and form a micro porous structure in the coating membrane. R1, phanidhar sastri1, ravikumar3, atin kalra1, pritam kanagale. Results of sem studies showed the formation of pores in the membrane from where the drug release occurred. Optimal design and numerical optimization technique was applied to find out the best formulation. Mar 21, 2016 controlled porosity osmotic pump tablet. Preparation of controlled porosity osmotic pump tablets for. Atenolol, controlled porosity osmotic pump, osmogents, semipermeable membrane. This video describes the inner parts of an alzet pump and how they operate to enable continuous delivery of experimental agents.
It was prepared by incorporating drugs in the core and coated with various types. The instant invention is directed to an osmotic pump comprising. Extended release controlled porosity osmotic pump formulations of model drug glipizide were developed using a wicking agent and a solubilizing agent. When these systems are exposed to water, low levels of water soluble additive is leached from polymeric material i. Apr 14, 2003 a controlled porosity osmotic pump based drug delivery system has been described in this study. Development and evaluation of controlled porosity osmotic pump for nifedipine and metoprolol combination rajagopal kumaravelrajan1, nallaperumal narayanan2 and venkatesan suba3 abstract background. It was concluded that osmotic pumping was the major mechanism governing drug release from mtctop. Formulation aspects in development of controlled porosity. The controlled porosity osmotic pump sciencedirect. Recent advances include various specific types of osmotic pump systems such as controlled porosity osmotic pump 20 cpop, osmotic bursting osmotic pump 21 obop, liquid orosliquid oral osmotic system 22 e. Formulation and optimization of controlled porosity osmotic. Also, the preparation of swellable controlled porosity osmotic pump tablet was facilitated by coating the core tablet with pore forming agent, thus eliminating the.
Drug release from the developed formulations osmotic pressure of the release media. The elementary osmotic pump is a new delivery system for drugs which delivers the drug by an osmotic process at a controlled rate. Osmotic pump for insoluble drugs multi chamber osmotic. Osmoticcontrolled release oral delivery system wikipedia. Development of controlled porosity osmotic pump of metoprolol. Glipizide osmotic tablets were evaluated for their flow properties, weight variation, hardness, friability and content uniformity.
A system that can deliver multidrug at a prolonged rate is very important for the treatment of. Pdf a novel controlled porosity osmotic pump system for. This device is known as swellable controlled porosity osmotic pump scpop. A controlled porosity osmotic pump based drug delivery system has been described in this study.
This article is from journal of basic and clinical pharmacy, volume 4. Cpop tablet is a novel drug delivery system with eternally. Push pull osmotic pump osmotic pump with nonexpanding second chamber specific types 1. The osmotic pressure is a colligative property of a solution in which the magnitude of. The porous osmotic pump tablets were designed using d. If the dmg does not posses sufficient osmotic p, a osmogent like nacl, glucose, sucrose, glycine etc. Through osmosis, water from the body is slowly drawn through the semipermeable membrane into the pump by osmotic agent residing in the engine compartment, which expands the osmotic agent and displaces a piston to.
Recent patent in controlled porosity osmotic pump request pdf. The coating of semi permeable membrane is done by a suitable coating method. Development and evaluation of controlled porosity osmotic. A significant milestone in oral ndds is osmotic drug delivery system. Enhancement of dissolution of glipizide from controlled porosity osmotic pump using a wicking agent and a solubilizing agent mahalaxmi. Osmotic drug delivery system as a part of modified release. Research open access development and evaluation of controlled.
Amsterdam printed in the netherlands 269 the controlled porosity osmotic pump gaylen ivi. Osmotic agent sodium chloride and pore former peg 400 was considered as independent variables. Preparation of controlled porosity osmotic pump tablets for salvianolic acid and optimization of the formulation using an artificial neural network method. Osmotic drug delivery system as a part of modified release dosage form. A a core which comprises a therapeutically effective amount of diltiazem lmalate and an effective buffering amount of sodium bitartrate surrounded by b a rate controlling water insoluble wall, having a fluid permeability of 6.
Review on controlled porosity osmotic pump tablets and its. The instant invention is directed to an osmotic pump, for the controlled release of diltiazem lmalate to an environment of use, said pump comprising. Formulation and evaluation of controlled porosity osmotic pump for oral delivery of ketorolac article pdf available december 2012 with 383 reads how we measure reads. Formulation and optimization of controlled porosity osmotic pump.
Controlledporosity osmotic pump tabletsan overview ajay. Cpop tablet is a novel drug delivery system with eternally drug delivery rate as characteristic and controlled with the osmotic pressure difference between inside and outside of spm as drug delivery power. Elementary osmotic pump the osmotic agent in the nondrug layer in 1974 theuwes invented elementary osmotic pump. They are the most reliable controlled drug delivery systems and could be employed as oral drug delivery systems. Pdf osmotic drug delivery system as a part of modified. Dec 09, 2014 types of pump application disease drug refrence osmotic pump clinical studies hypertensive, asthma metaprolol bauer et al. Controlled porosity osmotic pump cpop contains drug, osmogens, excipients in core and a coating of semipermeable membrane with water soluble additives.
Linear relationship between the release rate and external. Apr 11, 2011 a system that can deliver multidrug at a prolonged rate is very important for the treatment of various chronic diseases such as diabetes, asthma and heart disease. Controlled porosity osmotic pump tablet cpop system was designed to deliver nifedipine np and metoprolol mp in a controlled manner up to 12 h. The value complied with the literature data of controlled porosity osmotic pump l p. Chitosanbased controlled porosity osmotic pump for colon. However, drug release from oral controlled release. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed. Nov 06, 1990 the instant invention is directed to an osmotic pump comprising. Abstract of formulation of controlled porosity osmotic pump. The controlled porosity osmotic pump has been developed via incorporation of leachable watersoluble small molecules, such as sodium chloride, potassium chloride, urea, and sucrose etc.
Unlike the elementary osmotic pump eop which consists of an osmotic core with the drug surrounded by a semipermeable membrane drilled with a delivery orifice, controlled porosity of the membrane is accomplished by the use of different channeling agents in the coating. Pdl and cd were prepared in various formulations physical mixtures and presumed preformed complex. The study involves the use of taguchi orthogonal array. Pdf formulation and evaluation of controlled porosity osmotic. The objective of this work was to demonstrate that the incorporation of sulfobutylethercyclodextrin, sbe 7m cd, results in the complete and sustained release of a sparingly water. Basic components of controlled porous osmotic pump tablets. Implantable drugdispensing osmotic pump, shaped as a small rod with titanium housing. There is achance of dose dumping if the coating process is not well controlled. In this study, the core tablets consist of microcrystalline cellulose ph 101 and osmogents sodium chloride, mannitol, lactose were prepared by wet granulation method. Enhancement of dissolution of glipizide from controlled.
Formulation development and evaluation of controlled porosity. Lornoxicam release from controlled porosity osmotic pump was directly proportional to the pore former sorbitol and level of osmogen mannitol. Recent advances include development of the controlled porosity osmotic pump, and systems based on asymmetric membranes. A controlled porosity osmotic pump comprising a tablet coated with ethyl cellulose as a semipermeable membrane containing different levels of channeling agent has been developed for ketorolac tromethamine. Unlike the eop, the cpop had no preformed hole in the outer shell for the drug to be expelled out of. Drugs selected as candidate for osmotic system, should posses osmotic as the release rate of drug from osmotic system is directly proportional to the osmotic pressure of the core formulation. Osmotic devices are the most promising strategy based systems for controlled drug delivery. Unlike the elementary osmotic pump eop which consists of an osmotic core with the drug surrounded by a semipermeable membrane drilled with a delivery orifice, controlled porosity of the membrane. Controlled porosity osmotic pump tablet cpop system was designed to. The desired release profile was obtained by optimizing polymer concentration, channeling agent level, and plasticizer concentration. Article pdf available november 2015 with 825 reads. Research open access development and evaluation of.
Osmotic system releases a drug at a predetermined zero order delivery rate based on osmosis. Request pdf recent patent in controlled porosity osmotic pump the porous osmotic pump based drug delivery system for excellent controlled release of drug for 24 hrs. The present study is to develop controlled porosity osmotic pump tablets of lamivudine. Controlled porosity osmotic pump cpop controlled porosity osmotic pump is an osmotic tablet in which membrane contains water soluble leachable pore forming agents. Sep 16, 2015 alzet pumps deliver by the process of osmotic displacement. Granted application number ep85401157a other versions.
Controlled porosity osmotic pumpbased controlled release. Osmotic pump uses the basic principle of osmosis for release of drugs. The zeroorder release of water soluble, osmotically active agents from tablets coated with controlled porosity walls has been investigated. Background a system that can deliver multidrug at a prolonged rate is very important for the treatment of various chronic diseases such as diabetes, asthma and heart disease. At present, the controlled porosity osmotic pump cpop and the pushpull osmotic pump ppop are the most popular, being designed to avoid focused.
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